Urolithin A ke metabolite ea mala ea ellagic acid e nang le litlamorao tsa antioxidant le antiproliferative; e thibela kholo ea lisele tsa T24 le Caco-2 tse nang le litekanyetso tsa IC50 tsa 43.9 le 49 μM, ka ho latellana.

Lintho tsa 'mele le tsa lik'hemik'hale tsa urolithin A

Urolithin A ke metabolite ea bobeli ea motsoako oa tlhaho oa polyphenol ellagitannin. Liphuputso tsa morao-rao li bontšitse hore urolithin A e na le mesebetsi ea bohlokoa ea likokoana-hloko, e kang anti-oxidation, anti-inflammation, anti-botsofali, e laolang estrogen / androgen le ho etsa hore motho a ikutloe a le mong ka mitochondrial. Ka hona, urolithin A e phetha karolo ea bohlokoa ho thibela le ho phekola maloetse a mangata, a kang kankere, lefu la pelo, lefu la Alzheimer, lefu la Parkinson, lefu la tsoekere, botenya, lefu la masapo a masapo, joalo-joalo.

Mohloli le litšobotsi tsa sebopeho sa urolithin

Urolithin A (UroA) le urolithin B (UroB) li qalile ho aroloa ho tloha majoe a liphio tsa linku e le metabolites ea ellagic acid. Urolithin ea tlhaho ha e tloaelehe ka tlhaho, empa e le metabolite ea ellagic tannin kapa ellagic acid, e ajoa haholo ka moroto, mantle le bile ea liphoofolo tse anyesang tse kang batho, likhoto, litoeba, likhomo le likolobe. Espín et al. e fumane hore urolithin e ka matlafatsoa ho ea boemong bo phahameng ka har'a senya le gallbladder ea likolobe tsa Iberia, empa ha ho na katleho e totobetseng meleng e meng e kang mesifa, mafura, liphio, sebete le pelo. Liphuputso tsa liteko ho litoeba le batho li fumane hore urolithin le lihlahisoa tsa eona li ruisitsoe ka har'a lisele tsa tšoelesa ea senya 'me li boetse li ajoa le liseleng tsa motho.

Urolithin e hlahisoa ke ellagic acid e lahleheloang ke selikalikoe sa lactone mme butle-butle e e ntša metsi. Ka mor'a hore ellagic acid e lahleheloe ke lesale la eona la lactone, urolithin M-5 (UroM-5) e qala ho fumanoa. UroM-5 e dehydroxylated maemong a fapaneng ho hlahisa li-isomers tse ngata tsa tetrahydroxy urolithin tse kang urolithin D (UroD) le urolithin M-6 (UroM-6). Tetrahydroxy urolithin e lahleheloa ke sehlopha sa hydroxyl ho hlahisa trihydroxy urolithin tse kang urolithin C (UroC) le urolithin M-7 (UroM-7). Trihydroxy urolithin e lahleheloa ke sehlopha se seng sa hydroxyl ho hlahisa dihydroxy urolithin tse kang UroA le urolithin A isomer (isoUroA), 'me qetellong monohydroxy urolithin B (UroB) e fumanoa. Ho feta moo, isoUroA e bonolo ho dehydroxylate ho hlahisa UroB ho feta UroA. García-Villalba et al. E sebelisitse liteko tsa in vitro intestinal microbial metabolism ho sibolla metabolites ea ellagic acid, UroM-5, UroM-6, UroM-7, UroC, le urolithin E (UroE), e tiisang ka lekhetlo la pele hore urolithin e hlahisoa tlasa ts'ebetso ea limela tsa mala.

Urolithin A ke sehlahisoa sa limela tsa mala. Ka mor'a hore 'mele oa motho o je meroho le litholoana tse kang likharenate, monokotsoai le linate, libaktheria tsa mala le phenolic antioxidants tse ruileng litholoana le meroho tse ka holimo li arabela ho hlahisa urolithin A. Lilemong tsa morao tjena, liphuputso tse ling tsa preclinical li bontšitse hore urolithin A e thusa. ho ata ha mitochondrial le ho matlafatsa ts'ebetso ea eona, ka hona ho khothaletsa bophelo bo botle ba lisele, 'me phello e bohlokoa haholo ho mesifa, boko, manonyeletso le tse ling. likarolo.

Melemo e meng ea urolithin A: tahlehelo ea boima ba 'mele le mafura a visceral

Ho feta moo, urolithin A e thusa ho theola boima ba 'mele. Teko ea liphoofolo ka 2020 e bontšitse hore sehlopha sa lipatlisiso se fepa litoeba tse boima bo feteletseng ka litsela tse 4: lijo tse tloaelehileng, lijo tse nang le mafura a mangata, lijo tse nang le mafura a mangata tse tlatsitsoeng ka urolithin A ka mor'a libeke tsa 10, le lijo tse nang le mafura a mangata tse tlatsitsoeng ka urolithin B ka mor'a libeke tsa 10. Sephetho sa ho qetela e bile hore lihlopha tse peli tsa litoeba tse nonneng tse tlatsitsoeng ka urolithin li bile le phokotso e kholo ea boima ba 'mele le mafura a visceral.